Invasive fungal infections (IFI) are opportunistic illnesses in immunocompromised patients with the most common site of infection being the lungs. The morbidity and mortality associated with pulmonary IFI (PIFI) is significant but early diagnosis of has the potential to improve outcomes. Advancements in diagnostic approaches and therapeutic interventions are necessary to improve diagnostic efficiency and to establish evidence based therapeutic approaches.

The objective of this study is to compare current diagnostic strategies for pediatric pulmonary invasive fungal infections and to assess the effectiveness of management with empiric antifungal therapy versus undergoing invasive diagnostic procedures for patients. 

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The University of Minnesota is participating as a site in this study under leadership of Dr. Shane McAllister.